Emergence of Lineage IV Peste des Petits Ruminants Virus in Ethiopia: Complete Genome Sequence of an Ethiopian Isolate 2010

Summary Isolates of peste des petits ruminants virus ( PPRV ) can be segregated genetically into four lineages. For decades, lineages I – III have been reported across A frica whilst lineage IV has predominantly circulated across A sia. However, the lineage distribution is currently changing in A frica. Importantly, full genome sequence data for A frican field isolates have been lacking. Here, we announce the first complete genome sequence of a field isolate of peste des petits ruminants virus ( PPRV ) from E ast A frica. This isolate was derived from the intestine of a goat suffering from severe clinical disease during the 2010 outbreak in E thiopia. The full genome sequence of this isolate, PPRV E thiopia/2010, clusters genetically with other lineage IV isolates of PPRV , sharing high levels of sequence identity across the genome. Further, we have carried out a phylogenetic analysis of all of the available A frican partial N gene and F gene PPRV sequences to investigate the epidemiology of PPRV with a focus on the emergence of different lineages of PPRV in A frica.