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Emergence of Lineage IV Peste des Petits Ruminants Virus in Ethiopia: Complete Genome Sequence of an Ethiopian Isolate 2010
Author(s) -
Muniraju M.,
Mahapatra M.,
Ayelet G.,
Babu A.,
Olivier G.,
Munir M.,
Libeau G.,
Batten C.,
Banyard A. C.,
Parida S.
Publication year - 2016
Publication title -
transboundary and emerging diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.392
H-Index - 63
eISSN - 1865-1682
pISSN - 1865-1674
DOI - 10.1111/tbed.12287
Subject(s) - peste des petits ruminants virus , peste des petits ruminants , biology , lineage (genetic) , genome , phylogenetic tree , virology , outbreak , whole genome sequencing , phylogenetics , gene , genetics , virus , evolutionary biology
Summary Isolates of peste des petits ruminants virus ( PPRV ) can be segregated genetically into four lineages. For decades, lineages I – III have been reported across A frica whilst lineage IV has predominantly circulated across A sia. However, the lineage distribution is currently changing in A frica. Importantly, full genome sequence data for A frican field isolates have been lacking. Here, we announce the first complete genome sequence of a field isolate of peste des petits ruminants virus ( PPRV ) from E ast A frica. This isolate was derived from the intestine of a goat suffering from severe clinical disease during the 2010 outbreak in E thiopia. The full genome sequence of this isolate, PPRV E thiopia/2010, clusters genetically with other lineage IV isolates of PPRV , sharing high levels of sequence identity across the genome. Further, we have carried out a phylogenetic analysis of all of the available A frican partial N gene and F gene PPRV sequences to investigate the epidemiology of PPRV with a focus on the emergence of different lineages of PPRV in A frica.

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