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Serological Evidence Indicates that Foot‐and‐Mouth Disease Virus Serotype O, C and SAT 1 are most Dominant in E ritrea
Author(s) -
Tekleghiorghis T.,
Moormann R. J. M.,
Weerdmeester K.,
Dekker A.
Publication year - 2014
Publication title -
transboundary and emerging diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.392
H-Index - 63
eISSN - 1865-1682
pISSN - 1865-1674
DOI - 10.1111/tbed.12065
Subject(s) - serotype , serology , foot and mouth disease , virology , foot and mouth disease virus , antibody , virus , biology , neutralization , aphthovirus , immunology
Summary Foot‐and‐mouth disease ( FMD ) is endemic in E ritrea and in most parts of A frica. To be able to control FMD using vaccination, information on the occurrence of various foot‐and‐mouth disease serotypes in E ritrea is needed. In this cross‐sectional study, 212 sera samples were collected from FMD infected and recovered animals in E ritrea. These samples were tested for the presence of antibodies against FMD non‐structural proteins ( NSP ) and neutralizing antibodies against six of the seven (all but SAT 3) serotypes of FMD virus ( FMDV ). Of these, 67.0% tested positive to non‐structural protein antibodies in the FMD NS ELISA . By virus neutralization, FMDV serotype O antibodies were shown to be the most dominant (approximately 50%). Virus neutralization test results indicate that infection with serotype C and SAT 1 might have occurred, although there are no reports of isolation of these two serotypes. Because the samples were not randomly selected, further random serological surveillance in all age group animals is necessary both to estimate the prevalence of FMD in the country and to confirm the serological results with serotype C and SAT 1.

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