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Proper Quality Control of Formulated Foot‐and‐Mouth Disease Vaccines in Countries with Prophylactic Vaccination is Necessary
Author(s) -
Jamal S. M.,
Shah S. I.,
Ali Q.,
Mehmood A.,
Afzal M.,
Afzal M.,
Dekker A.
Publication year - 2014
Publication title -
transboundary and emerging diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.392
H-Index - 63
eISSN - 1865-1682
pISSN - 1865-1674
DOI - 10.1111/tbed.12051
Subject(s) - foot and mouth disease , vaccination , serotype , medicine , immune system , inactivated vaccine , adverse effect , virology , immunology , virus
Summary Vaccination is considered as an important tool to control foot‐and‐mouth disease ( FMD ). A good quality vaccine containing relevant serotypes and matching strains is a pre‐requisite for vaccination to be effective. The present study investigated the quality of different brands of FMD vaccine available in Pakistan, including three locally produced and two imported products. All the vaccines were found free of bacterial or fungal contamination. No adverse effects were noted in suckling mice and buffalo calves inoculated with the vaccines, showing that the vaccines were sterile and safe. The humoral immune response to the FMD vaccines was determined in buffalo calves for 234 days post‐vaccination. Very low humoral immune responses against FMD serotypes O, A and Asia 1 viruses were detected to the locally produced vaccines. The imported vaccines, however, elicited a higher antibody response which persisted for a long period in one of the 2 vaccines. The present study highlights the need of assessing an independent vaccine quality control of finished FMD vaccine products.