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Association of HLA‐ DRB1 *09:01 with severe COVID ‐19
Author(s) -
Anzurez Alitzel,
Naka Izumi,
Miki Shoji,
NakayamaHosoya Kaori,
Isshiki Mariko,
Watanabe Yusuke,
NakamuraHoshi Midori,
Seki Sayuri,
Matsumura Takayuki,
Takano Tomohiro,
Onodera Taishi,
Adachi Yu,
Moriyama Saya,
Terahara Kazutaka,
Tachikawa Natsuo,
Yoshimura Yoshihiro,
Sasaki Hiroaki,
Horiuchi Hiroshi,
Miyata Nobuyuki,
Miyazaki Kazuhito,
Koga Michiko,
Ikeuchi Kazuhiko,
Nagai Hiroyuki,
Saito Makoto,
Adachi Eisuke,
Yotsuyanagi Hiroshi,
Kutsuna Satoshi,
Kawashima Akira,
Miyazato Yusuke,
Kinoshita Noriko,
Kouno Chiyoko,
Tanaka Kensuke,
Takahashi Yoshimasa,
Suzuki Tadaki,
Matano Tetsuro,
Ohashi Jun,
KawanaTachikawa Ai
Publication year - 2021
Publication title -
hla
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.347
H-Index - 99
eISSN - 2059-2310
pISSN - 2059-2302
DOI - 10.1111/tan.14256
Subject(s) - odds ratio , allele , covid-19 , locus (genetics) , human leukocyte antigen , genotype , medicine , hla drb1 , diabetes mellitus , immunology , disease , genetics , biology , infectious disease (medical specialty) , endocrinology , antigen , gene
HLA‐A, ‐C, ‐B, and ‐DRB1 genotypes were analyzed in 178 Japanese COVID‐19 patients to investigate the association of HLA with severe COVID‐19. Analysis of 32 common HLA alleles at four loci revealed a significant association between HLA‐DRB1*09:01 and severe COVID‐19 (odds ratio [OR], 3.62; 95% CI, 1.57–8.35; p = 0.00251 [permutation p value = 0.0418]) when age, sex, and other common HLA alleles at the DRB1 locus were adjusted. The DRB1*09:01 allele was more significantly associated with risk for severe COVID‐19 compared to preexisting medical conditions such as hypertension, diabetes, and cardiovascular diseases. These results indicate a potential role for HLA in predisposition to severe COVID‐19.