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Distribution of HLA allele frequencies in 82 Chinese individuals with coronavirus disease‐2019 (COVID‐19)
Author(s) -
Wang Wei,
Zhang Wei,
Zhang Jingjing,
He Ji,
Zhu Faming
Publication year - 2020
Publication title -
hla
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.347
H-Index - 99
eISSN - 2059-2310
pISSN - 2059-2302
DOI - 10.1111/tan.13941
Subject(s) - allele , human leukocyte antigen , covid-19 , biology , coronavirus , disease , allele frequency , pandemic , population , immunology , virology , genetics , medicine , infectious disease (medical specialty) , gene , antigen , environmental health
COVID‐19 is a respiratory disease caused by a novel coronavirus and is currently a global pandemic. HLA variation is associated with COVID‐19 because HLA plays a pivotal role in the immune response to pathogens. Here, 82 individuals with COVID‐19 were genotyped for HLA‐A, ‐B, ‐C, ‐DRB1, ‐DRB3/4/5, ‐DQA1, ‐DQB1, ‐DPA1, and ‐DPB1 loci using next‐generation sequencing (NGS). Frequencies of the HLA‐C*07:29 , C*08:01G , B*15:27 , B*40:06 , DRB1*04:06 , and DPB1*36:01 alleles were higher, while the frequencies of the DRB1*12:02 and DPB1*04:01 alleles were lower in COVID‐19 patients than in the control population, with uncorrected statistical significance. Only HLA‐C*07:29 and B*15:27 were significant when the corrected P ‐value was considered. These data suggested that some HLA alleles may be associated with the occurrence of COVID‐19.