Premium
Ectonucleoside triphosphate diphosphohydrolase 1 and 5′‐nucleotidase ecto gene polymorphisms and acute cellular rejection after liver transplantation
Author(s) -
Thude Hansjörg,
Onken Lena,
Kappauf Julia,
Dworak Markus,
Sterneck Martina,
Peine Sven,
Nashan Björn,
Koch Martina
Publication year - 2020
Publication title -
hla
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.347
H-Index - 99
eISSN - 2059-2310
pISSN - 2059-2302
DOI - 10.1111/tan.13892
Subject(s) - single nucleotide polymorphism , haplotype , snp , liver transplantation , gene , biology , transplantation , immunology , genetics , genotype , medicine
The single nucleotide polymorphisms (SNPs) rs11188513, rs7071836, rs10748643, rs9450279, rs4458647, and rs6922 map in the genes of ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1) and 5′‐nucleotidase ecto. We investigated whether these SNPs and haplotypes of these SNPs are associated with an acute cellular rejection after liver transplantation. A total of 69 recipients with an acute cellular rejection and 138 recipients without an acute cellular rejection were analyzed. Analyzed individually, no SNP demonstrates an association, but the haplotype rs11188513T‐rs7071836G‐rs10748643A of the ENTPD1 gene appeared more frequently in recipients without rejection and conversely, the haplotype rs11188513T‐rs7071836G‐rs10748643G of the ENTPD1 gene was more often represented in recipients with rejection. These two haplotypes seem to be important for the susceptibility of an acute cellular rejection after liver transplantation.