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Identification of the DRB4*01:03:01:02N null allele with HLA‐DRB1*04 in a Spanish donor
Author(s) -
AbadMolina Cristina,
VilchesMoreno Miriam,
CárdabaArranz Mario,
Nieto Antonio,
OrduñaDomingo Antonio
Publication year - 2019
Publication title -
hla
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.347
H-Index - 99
eISSN - 2059-2310
pISSN - 2059-2302
DOI - 10.1111/tan.13531
Subject(s) - null allele , allele , human leukocyte antigen , genetics , biology , haplotype
The association between the DRB4*01:03:01:02N null allele and the HLA‐DRB1*07~DQB1*03:03 haplotype has often been reported. Nevertheless, more unusual associations have also been found in other countries, such as its association with HLA‐DRB1*04 . HLA class I and II antigen typing is currently performed using DNA‐based methods, making it more difficult to identify null alleles than if serological methods were used. Furthermore, the DRB3/4/5 loci are not usually studied. However, the identification of non‐expressed HLA alleles is of great importance for transplantation so it is necessary to identify HLA antigen associations with null alleles and report these findings. In this paper, we describe the association of DRB4*01:03:01:02N null allele with DRB1*04 for the first time in Spain.