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Case report: A transplant candidate with unexpected serum reactivity against the 45KE eplet on HLA‐B alleles
Author(s) -
Cauquil Bastien,
Dautin Guillaume,
Duquesnoy Rene J.
Publication year - 2018
Publication title -
hla
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.347
H-Index - 99
eISSN - 2059-2310
pISSN - 2059-2302
DOI - 10.1111/tan.13331
Subject(s) - allele , antibody , human leukocyte antigen , immunology , medicine , genetics , biology , antigen , gene
This case report describes the serum antibody specificity against the 45KE eplet which had not been yet shown to be antibody‐verified. This antibody was produced by a 41‐year‐old European male with Berger's disease. His serum had HLA class I antibody reactivity as determined in IgG binding assays with single allele panels (OneLambda, ThermoFisher, Lot 8 and Lot 9). The HLAMatchmaker analysis revealed reproducible serum reactivity only with alleles carrying the 45KE eplet. The cause of this 45KE‐specific immunization is unknown because this male patient had never been transfused nor received a previous transplant, Moreover, his mother's HLA type did not have any 45KE‐carrying allele. This finding might be related to observations reported in the literature about the appearance of HLA‐reactive antibodies following influenza vaccination but this possibility could not be investigated.