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The distribution of HLA‐DRB3 alleles among HLA‐DRB1*03:01 ‐positive haplotypes
Author(s) -
Stingl Jankovic K.,
Grubic Z.,
Jakupic J.,
Burek Kamenaric M.,
Maskalan M.,
Zunec R.
Publication year - 2018
Publication title -
hla
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.347
H-Index - 99
eISSN - 2059-2310
pISSN - 2059-2302
DOI - 10.1111/tan.13328
Subject(s) - allele , haplotype , human leukocyte antigen , genetics , biology , polymorphism (computer science) , hla a , immunology , gene , antigen
HLA‐DRB3 allelic polymorphism on HLA‐DRB1*03:01 ‐positive haplotypes was investigated among 104 cadaveric donors typed for HLA‐A, ‐B, ‐DRB1, and ‐DRB3. Only HLA‐DRB3*01:01:02 and ‐DRB3*02:02:01:01 alleles were detected among HLA‐DRB1*03:01‐ positive individuals and their distribution depended on HLA‐B*08 presence: nearly all HLA‐B*08 ‐positive samples carried DRB3*01:01:02 , while HLA‐DRB3*02:02:01:01 was more frequent among HLA‐B*08 ‐negative subjects.