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Urdu speaking population from South India: Six extended haplotypes in linkage disequilibrium in Urdu Speaking Population
Author(s) -
Seshasubramanian V.,
Manisekar N. K.,
Sathishkannan A. D.,
Naganathan C.,
Nandakumar Y.,
Narayan S.
Publication year - 2018
Publication title -
hla
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.347
H-Index - 99
eISSN - 2059-2310
pISSN - 2059-2302
DOI - 10.1111/tan.13326
Subject(s) - linkage disequilibrium , haplotype , population , telugu , urdu , genetics , allele frequency , allele , sanger sequencing , biology , demography , dna sequencing , gene , sociology , natural language processing , linguistics , philosophy , computer science
HLA A:B:C:DRB1:DQB1 allele and haplotype frequencies were determined among Urdu speaking population from South India by Sanger and Next Generation Sequencing. Seventy bone marrow registry donors and 327 cord blood units from the Jeevan Stem Cell Foundation (part of Be The Cure Registry), Chennai, Tamilnadu were included in the study. No overall deviations from expected Hardy‐Weinberg equilibrium proportions were observed at all the five loci studied. The most frequent HLA class I alleles observed in this population were A*11:01:01, B*40:06:01, and C*06:02:01, showing a frequency of 15.87%, 12.72%, and 13.22%, respectively. The most frequent class II alleles observed in this population were DRB1*07:01:01 (15.62%) and DQB1*06:01:01 (21.41%). The top ranked haplotype A*01:01:01~B*57:01:01~C*06:02:01~DRB1*07:01:01~DQB1*03:03:02 (2.77%) reported in the present study, was the highly frequent haplotype found in Telugu speaking population who lived in the same region.