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Hepatocellular carcinoma: Prospects for natural killer cell immunotherapy
Author(s) -
Kumar N.,
Khakoo S. I.
Publication year - 2018
Publication title -
hla
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.347
H-Index - 99
eISSN - 2059-2310
pISSN - 2059-2302
DOI - 10.1111/tan.13275
Subject(s) - hepatocellular carcinoma , immunotherapy , immune system , immunology , carcinoma , liver disease , medicine , cancer research , biology
Liver disease is a growing cause of death in the United Kingdom and the incidence of hepatocellular carcinoma (HCC) is rising (http://www.cancerresearchuk.org/). The combination of an immunosuppressive environment within the liver and suboptimal host anti-tumour immune responses may account for the poor survival outcome of HCC. Understanding how tumours evade immune recognition coupled with new insights into the unique immunological environment within the liver will be critical to developing liver-specific immunotherapies.