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Impact of HLA‐DRB1 allele polymorphisms on control of HIV infection in a Peruvian MSM cohort
Author(s) -
OriolTordera B.,
Llano A.,
Ganoza C.,
Cate S.,
Hildebrand W.,
Sanchez J.,
Calle M. L.,
Brander C.,
Olvera A.
Publication year - 2017
Publication title -
hla
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.347
H-Index - 99
eISSN - 2059-2310
pISSN - 2059-2302
DOI - 10.1111/tan.13085
Subject(s) - cohort , human leukocyte antigen , human immunodeficiency virus (hiv) , immunogenetics , allele , immunology , viral load , biology , virology , medicine , demography , genetics , antibody , gene , antigen , sociology
Associations between HLA class II polymorphisms and HIV control were assessed in a Peruvian MSM cohort. Among 233 treatment naïve HIV+ individuals, DRB1*13:02 was linked to elevated viral loads ( P = .044) while DRB1*12:01 showed significantly lower viral set points ( P = .015) and restricted a dominant T cell response to HIV Gag p24 ( P = .038). The present work contributes to a better knowledge of the Peruvian immunogenetics and supports the important role of HLA class II restricted T cells in HIV control.