Impact of HLA‐DRB1 allele polymorphisms on control of HIV infection in a Peruvian MSM cohort | Zendy

OriolTordera B. | Zendy; Llano A. | Zendy; Ganoza C. | Zendy; Cate S. | Zendy; Hildebrand W. | Zendy; Sanchez J. | Zendy; Calle M. L. | Zendy; Brander C. | Zendy; Olvera A. | Zendy

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Impact of HLA‐DRB1 allele polymorphisms on control of HIV infection in a Peruvian MSM cohort

Author(s) -

OriolTordera B.,

Llano A.,

Ganoza C.,

Cate S.,

Hildebrand W.,

Sanchez J.,

Calle M. L.,

Brander C.,

Olvera A.

Publication year - 2017

Publication title -

hla

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.347

H-Index - 99

eISSN - 2059-2310

pISSN - 2059-2302

DOI - 10.1111/tan.13085

Subject(s) - cohort , human leukocyte antigen , human immunodeficiency virus (hiv) , immunogenetics , allele , immunology , viral load , biology , virology , medicine , demography , genetics , antibody , gene , antigen , sociology

Associations between HLA class II polymorphisms and HIV control were assessed in a Peruvian MSM cohort. Among 233 treatment naïve HIV+ individuals, DRB1*13:02 was linked to elevated viral loads ( P = .044) while DRB1*12:01 showed significantly lower viral set points ( P = .015) and restricted a dominant T cell response to HIV Gag p24 ( P = .038). The present work contributes to a better knowledge of the Peruvian immunogenetics and supports the important role of HLA class II restricted T cells in HIV control.

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