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Thirteen novel canine dog leukocyte antigen‐88 alleles identified by sequence‐based typing
Author(s) -
Venkataraman G. M.,
Kennedy L. J.,
Little M.T. E.,
Graves S. S.,
Harkey M. A.,
TorokStorb B. J.,
Storb R.
Publication year - 2017
Publication title -
hla
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.347
H-Index - 99
eISSN - 2059-2310
pISSN - 2059-2302
DOI - 10.1111/tan.13077
Subject(s) - allele , major histocompatibility complex , biology , human leukocyte antigen , hematopoietic stem cell transplantation , typing , histocompatibility , gene , transplantation , genetics , antigen , histocompatibility testing , immunology , mhc class i , stem cell , medicine , surgery
Major histocompatibility complex ( MHC ) genes in mammals include highly polymorphic class I and class II genes that are critical for donor‐recipient matching for transplantation. Dogs have served as an effective, directly translatable model for stem/progenitor cell transplantation. Previous analyses of MHC class I genes in dogs point to a single highly polymorphic gene, dog leukocyte antigen ( DLA )‐88, as an important factor in the success or failure of hematopoietic stem cell transplants. Fifty‐nine DLA ‐88 alleles have been identified and reported so far. Here, we extend this list by presenting 13 novel DLA ‐88 alleles found in domestic dogs.