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Identification of 400 novel alleles at the HLA ‐A, ‐B, ‐C, ‐ DRB1 , ‐ DQB1 loci from China Marrow Donor Program
Author(s) -
Chai X.,
Zhang H.,
Yang X.,
Yang F.,
Liu N.
Publication year - 2017
Publication title -
hla
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.347
H-Index - 99
eISSN - 2059-2310
pISSN - 2059-2302
DOI - 10.1111/tan.13071
Subject(s) - allele , genetics , frameshift mutation , homologous chromosome , biology , human leukocyte antigen , gene , microbiology and biotechnology , mutation , antigen
Four hundred novel human leukocyte antigen ( HLA ) alleles were identified in Chinese individuals: 100 HLA ‐A alleles, 100 HLA ‐B alleles, 101 HLA ‐C alleles, 28 HLA‐DRB1 alleles and 71 HLA‐DQB1 alleles. Comparing novel alleles with their most homologous allele, we found 72.73% non‐synonymous nucleotide substitutions, 21.13% silent mutations, 3.90% nonsense mutations and 3.25% frameshift mutation. 352 (88%) of the 400 novel alleles are single nucleotide substitution variants when compared with their most homologous alleles and other novel alleles differ from their most similar allele by more than 1 nucleotide substitutions, such as 2, 3, 5, 6, 8 and so on. Some of the novel alleles are characterized by long deletions or insertions, for example there is 23 bp deletion in the B*58:31N allele when compared to its most homologous allele B*58:01:01:01 .