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HLA class II alleles in Norwegian patients with coexisting type 1 diabetes and celiac disease
Author(s) -
Viken M. K.,
Flåm S. T.,
Skrivarhaug T.,
Amundsen S. S.,
Sollid L. M.,
Drivvoll A. K.,
Joner G.,
DahlJørgensen K.,
Lie B. A.
Publication year - 2017
Publication title -
hla
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.347
H-Index - 99
eISSN - 2059-2310
pISSN - 2059-2302
DOI - 10.1111/tan.12986
Subject(s) - haplotype , type 1 diabetes , allele , medicine , human leukocyte antigen , cohort , disease , gastroenterology , hla dqb1 , immunology , diabetes mellitus , genetics , endocrinology , biology , antigen , gene
Background Type 1 diabetes ( T1D ) and celiac disease ( CeD ) are 2 distinct diseases, but there is an increased risk of developing CeD for T1D patients. Both diseases are associated with HLA ‐class II alleles, such as DQB1 *02:01 and DQB1 *03:02 ; however, their risk contribution vary between the diseases. Materials and Methods We genotyped HLA‐DRB1 and – DQB1 in 215 patients with coexisting T1D and CeD identified from a T1D cohort, and compared them to patients with T1D (N = 487) and CeD (N = 327), as well as healthy controls (N = 368). Results The patients with coexisting T1D and CeD had an intermediate carrier frequency (72.8%) of the DRB1 *03:01‐ DQB1 *02:01‐ DQA1 *05:01 haplotype compared to T1D (64.1%) and CeD (88.7%) patients. The DRB1 *03:01‐ DQB1 *02:01‐ DQA1 *05:01/ DRB1 *04‐ DQB1 *03:02‐ DQA1 *03 haplotype combination, encoding DQ2 .5 and DQ8 molecules, was equally frequent among patients with both T1D and CeD (52.6%) and T1D patients (46.8%) but significantly lower in CeD patients (9.5%). Conclusion Overall, the patients with coexisting T1D and CeD had an HLA profile more similar to T1D patients than CeD patients.