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Cancer as a contagious disease
Author(s) -
Siddle H. V.
Publication year - 2017
Publication title -
hla
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.347
H-Index - 99
eISSN - 2059-2310
pISSN - 2059-2302
DOI - 10.1111/tan.12980
Subject(s) - biology , contagious disease , immune system , cancer , disease , immunology , malignant cells , major histocompatibility complex , pathology , medicine , genetics
Contagious cancers are malignant cells that are physically transferred between individuals as a natural allograft, forming new clonal tumours. These cancers are highly unusual, but have emerged in 2 mammalian species, the dog and the Tasmanian devil, as well as 4 species of bivalve. The transfer of malignant cells in mammals should initiate a robust immune response and although invertebrates have a less complex immune system, these species still have mechanisms that should prevent engraftment and protect against cellular parasitism. Here the naturally occurring contagious cancers are reviewed to determine what features are important and necessary for the emergence and spread of these types of cancer, with a focus on the mammalian contagious cancers and how they successfully cross histocompatibility barriers.