Premium
What is wrong with the regulatory T cells and foetomaternal tolerance in women with recurrent miscarriages?
Author(s) -
Craenmehr M. H. C.,
Heidt S.,
Eikmans M.,
Claas F. H. J.
Publication year - 2016
Publication title -
hla
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.347
H-Index - 99
eISSN - 2059-2310
pISSN - 2059-2302
DOI - 10.1111/tan.12737
Subject(s) - recurrent miscarriage , miscarriage , medicine , intervention (counseling) , abortion , pregnancy , obstetrics , immunology , biology , psychiatry , genetics
Couples of whom the woman has had a miscarriage have two major concerns: the cause and possible risk of recurrence. Unfortunately, a significant proportion of cases of recurrent miscarriage (RM) remain unexplained despite detailed investigation. Because data suggest that regulatory T cells (Treg) are involved in the maternal acceptance of the allogeneic foetus, RM could possibly be explained by a disturbance of the Treg network. The possible role of Tregs in RM is described in this review, as well as their potential application in diagnostics and therapeutic intervention trials.