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The profile of HLA‐DRB1 alleles in Arabs with type 1 diabetes; meta‐analyses
Author(s) -
Hamzeh A. R.,
Nair P.,
Al Ali M. T.
Publication year - 2016
Publication title -
hla
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.347
H-Index - 99
eISSN - 2059-2310
pISSN - 2059-2302
DOI - 10.1111/tan.12717
Subject(s) - allele , human leukocyte antigen , genetics , meta analysis , odds ratio , locus (genetics) , hla dq , biology , type 1 diabetes , demography , gene , diabetes mellitus , medicine , haplotype , antigen , sociology , endocrinology
Genes from the HLA complex have a major contribution in type 1 diabetes ( T1D ), which results from an interplay between environmental and genetic factors. The latter can explain some of the geographic variability in T1D occurrence around the world. Of a particular importance in this regard are the HLA‐DR , ‐ DP and ‐ DQ loci. Consequently, we aimed at elucidating the collective genetic profiles of various alleles relating to HLA‐DRB1 and ‐ DP in T1D patients throughout the Arab World using the tools of meta‐analysis. As for HLA‐DQA1 and DQB1 alleles; this analysis was completed and published previously (see Introduction). As a result of limited availability of relevant studies of the HLA‐DP locus, only HLA‐DRB1 alleles were tackled in this paper. Our study showed that significant increases in T1D risk resulted from harboring the alleles DRB1 *03:01 and *04:05 ( odds ratio 7.76 and 7.52, respectively). DRB1 *04:01 and *04:02 were also predisposing for T1D in Arabs. Very strong evidence supported the protective effects of DRB1 *10:01 , *13:01 , *15:02 and *16:01 , with low heterogeneity and no publication bias. The results from the series of meta‐analyses performed in this study help to complete the global genetic epidemiological map of T1D by providing statistically robust data from the Arab World.