
Multi‐wavelength, handheld laser speckle imaging for skin evaluation
Author(s) -
Zieger Michael,
Kaatz Martin,
Springer Steffen,
Riesenberg Rainer,
Wuttig Andreas,
Kanka Mario,
Stanca Sarmiza,
Reble Carina,
Khazaka Georg,
Sieg Robin,
De Gregorio Marco,
Sattler Martin,
Fischer Frank
Publication year - 2021
Publication title -
skin research and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.521
H-Index - 69
eISSN - 1600-0846
pISSN - 0909-752X
DOI - 10.1111/srt.12959
Subject(s) - speckle pattern , laser , optics , speckle imaging , materials science , human skin , speckle noise , wavelength , biomedical engineering , optoelectronics , medicine , physics , genetics , biology
Objective A handheld device was developed and qualified for in vivo human skin evaluation using laser speckle imaging technology. Methods Each laser speckle device prototype allows the choice of up to three different laser wavelengths in the range of 400 nm to 800 nm in total. Speckle pattern analysis gives various speckle parameters, for example, speckle contrast, speckle size, speckle modulation or fractal dimension. The developed laser speckle device prototypes were evaluated investigating three skin issues. Results We receive reproducible results from the speckle imaging device. For skin ageing, we found significant changes within three age groups. The effect of a methyl nicotinate treatment was clearly visible and quantifiable using a moorFLPI device as well as our speckle imaging device. In terms of basal cell carcinoma diagnosis, we found significant differences between normal and diseased skin, even though the number of samples was limited. Conclusion As shown with first application examples, it was possible to demonstrate the potential of the method for skin evaluation in vivo.