Open AccessImaging reveals distinct textures at three infant skin sites and reflects skin barrier status
Author(s) -
Visscher Marty,
Narendran Vivek
Publication year - 2021
Publication title -
skin research and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.521
H-Index - 69
eISSN - 1600-0846
pISSN - 0909-752X
DOI - 10.1111/srt.12925
Subject(s) - stratum corneum , diaper dermatitis , skin barrier , transepidermal water loss , dermatology , medicine , epidermolytic hyperkeratosis , rash , pathology , hyperkeratosis
Background Infant diaper dermatitis (DD) is a prevalent condition due to multiple, interactive factors including increased skin hydration, irritant exposure, and increased skin pH. We examined diaper dermatitis vs within diaper and non‐diaper controls over time and characterized the association of skin color and texture relative to skin barrier integrity, hydration, and pH. Materials and Methods The prospective study included 46 infants with DD at well‐child visits. Skin integrity was evaluated over 15 days, including visual skin condition, rate of stratum corneum transepidermal water accumulation, hydration, pH, and skin color and texture from high‐resolution digital skin surface images. Effects by site and time were evaluated with general linear models. Results Six distinct texture patterns were observed. All three sites differed significantly for texture class frequency. Normal dermatoglyphics were more frequent for non‐diaper vs both within diaper and rash sites. Dermatoglyphics with marked furrows or lines (class 3) were common within diaper vs rash but not for non‐diaper vs within diaper. Streaks were highest for DD and lowest for non‐diaper. Flat regions were more frequent DD. Barrier integrity, that is, moisture accumulation rate, was lower for normal dermatoglyphics than streaks or flat texture. DD severity decreased over 15 days. Barrier properties of within diaper and non‐diaper areas were not well‐differentiated. Conclusion The incidence of streak texture in the within diaper high magnification images was high despite being visually normal. This finding suggests that it is an “early indicator” of skin damage and may be clinically useful for early detection and treatment.