Open AccessSkin blood flow response to topically applied methyl nicotinate: Possible mechanisms
Author(s) -
Elawa Sherif,
Mirdell Robin,
Farnebo Simon,
Tesselaar Erik
Publication year - 2020
Publication title -
skin research and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.521
H-Index - 69
eISSN - 1600-0846
pISSN - 0909-752X
DOI - 10.1111/srt.12807
Subject(s) - lidocaine , vasodilation , microcirculation , nitric oxide , prilocaine , erythema , prostaglandin , medicine , pharmacology , laser doppler velocimetry , perfusion , cyclooxygenase , provocation test , anesthesia , sensory nerve , chemistry , blood flow , sensory system , dermatology , endocrinology , pathology , neuroscience , biochemistry , biology , alternative medicine , enzyme
Background Methyl nicotinate (MN) induces a local cutaneous erythema in the skin and may be valuable as a local provocation in the assessment of microcirculation and skin viability. The mechanisms through which MN mediates its vascular effect are not fully known. The aim of this study was to characterize the vasodilatory effects of topically applied MN and to study the involvement of nitric oxide (NO), local sensory nerves, and prostaglandin‐mediated pathways. Methods MN was applied on the skin of healthy subjects in which NO‐mediated (L‐NMMA), nerve‐mediated (lidocaine/prilocaine), and cyclooxygenase‐mediated (NSAID) pathways were selectively inhibited. Microvascular responses in the skin were measured using laser speckle contrast imaging (LSCI). Results NSAID reduced the MN‐induced perfusion increase with 82% ( P < .01), whereas lidocaine/prilocaine reduced it with 32% ( P < .01). L‐NMMA did not affect the microvascular response to MN. Conclusion The prostaglandin pathway and local sensory nerves are involved in the vasodilatory actions of MN in the skin.