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Chromametric assessment of drug skin tolerance: A comparative study between Africans and Caucasians skins
Author(s) -
Sounouvou Hope T.,
Lechanteur Anna,
QuetinLeclercq Joëlle,
Piel Géraldine,
Donneau AnneFrançoise,
Gbaguidi Fernand,
Evrard Brigitte
Publication year - 2020
Publication title -
skin research and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.521
H-Index - 69
eISSN - 1600-0846
pISSN - 0909-752X
DOI - 10.1111/srt.12804
Subject(s) - skin color , dermatology , medicine , skin type , skin irritation , computer science , artificial intelligence
Background/Aims During dermatological forms development, one of the simplest non‐invasive techniques used to evaluate cutaneous tolerance of formulations is to monitor the color changes using a tristimulus chromameter. Most published tolerance studies involving chromametric measurements are performed on Caucasian subjects. However, in the context of drug formulation for African‐type populations, it is not always relevant to transpose tolerance results obtained on Caucasians populations to African‐type ones due to histological ethnic differences of the skin. The goal of this work was to assess whether tristimulus chromameter can be used to highlight color variations following the application of dermatological topics on black skin in order to validate skin tolerance studies made on African‐type subjects. Materials and Methods After application of two commercial creams with opposite side effects (skin irritation and skin blanching) in both Africans and Caucasians populations, color variations were evaluated using a tristimulus chromameter in L * a * b * color system and compared between both populations. L * indicating color brightness, a * represents green and red directions and b * represents blue and yellow directions. Results While skin irritation resulted in a significant increase of a * parameter in both studied populations, the skin blanching resulted in a decrease of a * associated with an increase of L * . Conclusion We established that tristimulus chromameter can be used to achieve in vivo skin tolerance study of dermatologic formulations in Africans despite their dark skin even though it appeared less sensitive. This study can speed up the development of dermatological forms dedicated to Africans and/or Caucasians subjects.

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