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Application of parelectric spectroscopy to detect skin cancer—A pilot study
Author(s) -
ArnoldBrüning Frederike S.,
Blaschke Tobias,
Kramer Klaus,
Lademann Jürgen,
Thiede Gisela,
Fluhr Joachim W.,
Patzelt Alexa,
Meinke Martina C.
Publication year - 2020
Publication title -
skin research and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.521
H-Index - 69
eISSN - 1600-0846
pISSN - 0909-752X
DOI - 10.1111/srt.12785
Subject(s) - skin cancer , basal cell carcinoma , melanoma , medicine , cancer , spectroscopy , human skin , dermatology , basal cell , pathology , cancer research , biology , physics , quantum mechanics , genetics
Background The early detection of skin cancer is still challenging and calls for objective, fast diagnostic, and ideally non‐invasive methods in order to leave the potentially malignant tumor cells unaltered. In this paper, the parelectric spectroscopy was applied to evaluate the potential of a non‐invasive detection of basal cell carcinoma (BCC) and malignant melanoma. Materials and Methods A prototype of parelectric spectroscopy was used to investigate non‐invasively dipole density and mobility of suspicious skin lesions. The differences in investigated tissue were analyzed compared to pathohistological findings in a clinical study on 51 patients with suspected BCC and malignant melanoma. Results The non‐invasive parelectric spectroscopy could differentiate between normal skin, BCC, and melanoma but failed to distinguish between different types of skin cancer. The data were normalized to unsuspected nearby skin because the different skin locations influence dipole density and mobility. Conclusion The results of the pilot study indicate that the parelectric spectroscopy might be an additional, useful non‐invasive diagnostic procedure to distinguish between normal skin and skin cancer.

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