Open AccessUse of Raman spectroscopy in the assessment of skin after CO 2 ablative fractional laser surgery on acne scars
Author(s) -
Chiwo Fernando Sebastian,
Guevara Edgar,
RamírezElías Miguel Ghebre,
CastilloMartínez Claudio Cayetano,
OsornioMartínez Carlos Eduardo,
CabreraAlonso Rodrigo,
PérezAtamoros Francisco,
González Francisco Javier
Publication year - 2019
Publication title -
skin research and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.521
H-Index - 69
eISSN - 1600-0846
pISSN - 0909-752X
DOI - 10.1111/srt.12722
Subject(s) - ablative case , scars , acne scars , acne , medicine , dermatology , wound healing , laser , human skin , surgery , radiation therapy , optics , physics , biology , genetics
Background Ablative fractional laser surgery is a common technique for treating acne scars. However, an in vivo and noninvasive analysis of the histologic variations between acne skin and the resulting resurfaced skin is needed in order to evaluate the wound healing process of the scars induced by the ablative fractional laser surgery. Materials and Methods Nine patients with acne scars underwent a single treatment with a CO 2 ablative fractional laser surgery. Collagen presence on the resurfaced skin was noninvasively assessed by means of Raman spectroscopy and principal component analysis. Results Principal component analysis shows that all the patients presented a collagen regeneration on the resurfaced skin after the laser treatment. Conclusion Collagen plays a crucial role in the wound healing process. By assessing the collagen presence on the skin, it was possible to quantify the regenerative effects of the ablative fractional laser in a noninvasive way.