Open AccessSplit‐axilla comparison study of 0.5‐MHz, invasive, bipolar radiofrequency treatment using insulated microneedle electrodes for primary axillary hyperhidrosis
Author(s) -
Cho S. B.,
Park J.,
Zheng Z.,
Yoo K. H.,
Kim H.
Publication year - 2019
Publication title -
skin research and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.521
H-Index - 69
eISSN - 1600-0846
pISSN - 0909-752X
DOI - 10.1111/srt.12591
Subject(s) - interquartile range , axilla , medicine , nuclear medicine , surgery , breast cancer , cancer
Abstract Background Energy‐delivering devices can be used to induce thermal coagulation of the eccrine sweat glands for treating primary axillary hyperhidrosis ( PAH ). Objective The objective of this study was to compare the efficacy and safety of invasive, bipolar radiofrequency ( RF ) treatment for PAH . Methods A split‐axilla study was performed to compare the clinical outcomes of 0.5 MH z, invasive, bipolar RF treatment with treatment settings of a longer conduction time and lower power ( LC / LP ) vs a shorter conduction time and higher power ( SC / HP ) for treating PAH . Results The in vivo study revealed median hyperhidrosis disease severity scale scores of 1.5 (interquartile range [ IQR ], 1‐2) at 1 month and 1 ( IQR , 1‐2) at 3 months after treatment with the LC / LP setting, compared to baseline. Meanwhile, the other side of the axillae treated with the SC / HP setting showed scores of 2 ( IQR , 2‐2) at 1 month and 2 ( IQR , 1.25‐2) at 3 months. Analysis via a linear mixed model revealed a significant interaction (group, P = .011; time, P < .001; and group × time, P = .048) between treatment group and time. Conclusion PAH can be effectively and safely treated with invasive, multilayered, multiple‐pass, 0.5‐ MH z, bipolar RF treatment, particularly with LC / LP .