Open AccessRelationship of hyaluronan and HYBID ( KIAA 1199) expression with roughness parameters of photoaged skin in Caucasian women
Author(s) -
Yoshida H.,
Komiya A.,
Ohtsuki R.,
KusakaKikushima A.,
Sakai S.,
Kawabata K.,
Kobayashi M.,
Nakamura S.,
Nagaoka A.,
Sayo T.,
Okada Y.,
Takahashi Y.
Publication year - 2018
Publication title -
skin research and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.521
H-Index - 69
eISSN - 1600-0846
pISSN - 0909-752X
DOI - 10.1111/srt.12467
Subject(s) - wrinkle , dermis , extracellular matrix , skin aging , staining , immunohistochemistry , gene expression , melanin , photoaging , skin color , pathology , medicine , dermatology , chemistry , biology , microbiology and biotechnology , gene , biochemistry , gerontology , artificial intelligence , computer science
Background Hyaluronan ( HA ) is an important constituent of extracellular matrix ( ECM ) in the skin, and HA degradation mediated by HYBID ( KIAA 1199) is suggested to be implicated in facial skin wrinkling in Japanese women. Ethnic difference in skin wrinkle formation is known between Caucasian and Japanese women, but no information is available for the relations of HA and HYBID expression levels with skin wrinkling in Caucasian women. Methods The skin surface roughness at the eye corner of the Caucasian female subjects was measured, and the skin specimens biopsied from the same areas were subjected to microarray gene analysis, HA staining, and immunohistochemistry for HYBID . Results Among the ECM genes and those related to ECM metabolism, only HYBID expression levels positively correlated with the skin roughness parameters. When the skin sample groups with high expression of HYBID or low expression of HYBID were compared, the HA staining intensity and the ratio of HYBID ‐immunoreactive cells to total cells in the superficial dermis were significantly reduced and increased in the high‐ HYBID ‐expression group compared with the low‐ HYBID ‐expression group, respectively. Conclusion Our data suggest that like Japanese women, HYBID ‐mediated reduction of HA in the superficial dermis is involved in the formation of wrinkles in Caucasian women.