Open AccessFollow‐up of solar lentigo depigmentation with a retinaldehyde‐based cream by clinical evaluation and calibrated colour imaging
Author(s) -
Questel E.,
Durbise E.,
Bardy A.L.,
Schmitt A.M.,
Josse G.
Publication year - 2015
Publication title -
skin research and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.521
H-Index - 69
eISSN - 1600-0846
pISSN - 0909-752X
DOI - 10.1111/srt.12182
Subject(s) - magnification , depigmentation , medicine , dermatology , melasma , artificial intelligence , computer science
Background and Objective To assess an objective method evaluating the effects of a retinaldehyde‐based cream ( RA ‐cream) on solar lentigines; 29 women randomly applied RA ‐cream on lentigines of one hand and a control cream on the other, once daily for 3 months. Methods A specific method enabling a reliable visualisation of the lesions was proposed, using high‐magnification colour‐calibrated camera imaging. Assessment was performed using clinical evaluation by Physician Global Assessment score and image analysis. Luminance determination on the numeric images was performed either on the basis of 5 independent expert's consensus borders or probability map analysis via an algorithm automatically detecting the pigmented area. Results Both image analysis methods showed a similar lightening of Δ L * = 2 after a 3‐month treatment by RA ‐cream, in agreement with single‐blind clinical evaluation. Conclusion High‐magnification colour‐calibrated camera imaging combined with probability map analysis is a fast and precise method to follow lentigo depigmentation.