Open AccessImproved methods for selective cryolipolysis results in subcutaneous fat layer reduction in a porcine model
Author(s) -
Kwon T.R.,
Yoo K. H.,
Oh C. T.,
Shin D. H.,
Choi E. J.,
Jung S. J.,
Hong H.,
Choi Y. S.,
Kim B. J.
Publication year - 2015
Publication title -
skin research and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.521
H-Index - 69
eISSN - 1600-0846
pISSN - 0909-752X
DOI - 10.1111/srt.12176
Subject(s) - medicine , body contouring , subcutaneous fat , adipose tissue , contouring , adipocyte , apocrine , liposuction , pathology , cryosurgery , endocrinology , surgery , obesity , engineering drawing , weight loss , engineering
Background/aims Cryolipolysis is a noninvasive method for the selective reduction of localized fat tissues. It has demonstrated efficacy in both clinical and preclinical trials; however, despite its popularity, its mechanisms of action and evaluation methods are not yet fully defined. The purpose of this study was to improved methods for cryolipolysis using a porcine model. Methods The abdomens of female PWG micro‐pigs were treated with a cooling device ( CRYOLIPO II ™ ), and we examined the treatment effects using photography, three‐dimensional photography, ultrasound, gross, and microscopic pathology, and serum lipid level analyses in order to determine the mechanism of action, efficacy, and safety of CRYOLIPO II ™ . Results CRYOLIPO II ™ successfully reduced abdominal fat in our porcine model. Gross and microscopic histological results confirmed the noninvasive cold‐induced selective subcutaneous fat destruction, and showed increases in pre‐adipocyte differentiation and in the activation of lipid catabolism. In particular, we found that CRYOLIPO II ™ may increase PPAR δ (delta) levels in adipose tissue at 30–60 days post‐treatment. Conclusion Fat reduction by cryolipolysis was successfully achieved in our porcine model. Thus, our findings indicate that CRYOLIPO II ™ may be a promising fat reduction device for body contouring and fat reduction in humans, and that cryolipolysis exerts its effects, at least partly, by targeting the PPAR δ signaling pathway. These results show that both investigative and diagnostic potentials capacity.