Open AccessReduction in facial hyperpigmentation after treatment with a combination of topical niacinamide and tranexamic acid: a randomized, double‐blind, vehicle‐controlled trial
Author(s) -
Lee Do Hyun,
Oh In Young,
Koo Kyo Tan,
Suk Jang Mi,
Jung Sang Wook,
Park Jin Oh,
Kim Beom Joon,
Choi Yoo Mi
Publication year - 2014
Publication title -
skin research and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.521
H-Index - 69
eISSN - 1600-0846
pISSN - 0909-752X
DOI - 10.1111/srt.12107
Subject(s) - niacinamide , medicine , tranexamic acid , hyperpigmentation , regimen , dermatology , phototype , randomized controlled trial , melasma , surgery , nicotinamide , blood loss , chemistry , biochemistry , enzyme
Background Facial hyperpigmentation occurs in multiple conditions. In addition, many Asian women desire a lighter skin color. Thus, there is a need for the development of skin lightening agents, and niacinamide and tranexamic acid ( TXA ) are promising candidates. Objective To assess the effectiveness of a combination of niacinamide and TXA as a topical moisturizing formulation for treatment of irregular facial pigmentation. Materials and Methods A total of 42 Korean women (age range: 30–60 years) who were not pregnant, nursing, or undergoing any concurrent therapy were enrolled in this study for 8 weeks. Subjects used a twice‐daily regimen of either a moisturizing cream containing 2% niacinamide + 2% TXA (test formulation; n = 21) or cream vehicles (vehicle control; n = 21) in addition to an assigned sunscreen each morning. Pigmentation was measured objectively using a mexameter and chromameter, in addition to physicians' assessment using clinical photographs. Results The niacinamide + TXA formulation regimen was significantly ( P < 0.05) more effective than the vehicle control formulation regimen in reducing the appearance of pigmentation. Conclusion A formulation containing the combination of niacinamide + TXA reduced the appearance of irregular pigmentation, providing an effect beyond that achieved with sunscreen.