Open AccessMorphological changes in skin of different phototypes under the action of topical corticosteroid therapy and tacrolimus
Author(s) -
Shlivko I. L.,
Kamensky V. A.,
Donchenko E.V.,
Agrba P.
Publication year - 2014
Publication title -
skin research and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.521
H-Index - 69
eISSN - 1600-0846
pISSN - 0909-752X
DOI - 10.1111/srt.12095
Subject(s) - phototype , tacrolimus , medicine , dermatology , corticosteroid , clobetasol propionate , atrophy , vitiligo , optical coherence tomography , ophthalmology , surgery , pathology , transplantation
Background/purpose The present study aimed to investigate the influence of topical corticosteroid therapy and tacrolimus on morphological indices of different skin phototypes and to optimize topical therapy using the OCT technique. Methods Twenty healthy volunteers aging from 20 to 30 (14 men and 6 women) took part in the study: 10 persons with skin phototype I, II and 10 persons with skin phototype V, VI . Morphological state of the skin was assessed before and during application of topical steroids of different strength and calciumneurin inhibitors for 49 days. Morphological state was studied in vivo using the optical coherence tomograph. Results Morphological manifestations of skin atrophy with the use of clobetasol propionate appear earlier than with the use of hydrocortisone 17‐butyrate; this process was faster in representatives of groups V, VI . Epidermal thinning in the zone of tacrolimus application was not recorded in any phototype. Conclusion Recording of early preclinical signs of epidermis thinning in the course of OCT follow‐up may be an indication for changing the corticosteroid therapy by calciumneurin inhibitors, which will permit to individualize the therapy, to increase its efficacy, and to minimize the possibility of complications in each particular case.