Open AccessTransepidermal water loss in erythrodermic patients of various aetiologies
Author(s) -
Mohd Noor Noorlaily,
Hussein Suraiya H.
Publication year - 2013
Publication title -
skin research and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.521
H-Index - 69
eISSN - 1600-0846
pISSN - 0909-752X
DOI - 10.1111/srt.12048
Subject(s) - transepidermal water loss , erythroderma , medicine , abdomen , dermatology , significant difference , etiology , surgery , pathology , stratum corneum
Background/purpose Despite its severity not much work has been done to explore the barrier function in patients with erythroderma. This study compares TEWL between skin of healthy subjects and erythrodermic patients of various aetiologies and at different sites. We also assess TEWL between patients with acute and chronic erythroderma. Methods Twenty‐five erythrodermic patients and 26 age, race and sex‐matched healthy controls were recruited. TEWL measurements were performed at five sites; right cheek, left volar forearm, abdomen, upper back and right calf using Tewameter TM 210. Results TEWL in erythrodermic patients were significantly higher than healthy individuals at all the sites ( P < 0.001). There were significant differences in TEWL between different anatomical sites in controls ( P < 0.001) but not in patients. The highest TEWL for the patient and control groups were that of the abdomen and the right cheek respectively. Acute erythrodermic patients ( n = 9) seemed to have a higher TEWL than chronic erythrodermic patients ( n = 16) although the differences were not statistically significant. There was no significant difference in TEWL among erythrodermic patients of various aetiologies. Conclusion Erythrodermic skin regardless of aetiology has much higher TEWL compared to normal skin. Differences in TEWL among various anatomical sites observed in normal skin were not seen in erythroderma.