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Autophagy is required for performance adaptive response to resistance training and exercise‐induced adult neurogenesis
Author(s) -
CodinaMartínez Helena,
FernándezGarcía Benjamín,
DíezPlanelles Carlos,
Fernández Álvaro F.,
Higarza Sara G.,
FernándezSanjurjo Manuel,
DíezRobles Sergio,
IglesiasGutiérrez Eduardo,
TomásZapico Cristina
Publication year - 2020
Publication title -
scandinavian journal of medicine and science in sports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.575
H-Index - 115
eISSN - 1600-0838
pISSN - 0905-7188
DOI - 10.1111/sms.13586
Subject(s) - neurogenesis , autophagy , doublecortin , hippocampal formation , hippocampus , medicine , neuroplasticity , endurance training , endocrinology , neuroscience , psychology , biology , dentate gyrus , biochemistry , apoptosis
Endurance training promotes exercise‐induced adaptations in brain, like hippocampal adult neurogenesis and autophagy induction. However, resistance training effect on the autophagy response in the brain has not been much explored. Questions such as whether partial systemic autophagy or the length of training intervention affect this response deserve further attention. Therefore, 8‐week‐old male wild‐type (Wt; n = 36) and systemic autophagy‐deficient ( atg4b −/− , KO; n = 36) mice were randomly distributed in three training groups, resistance (R), endurance (E), and control (non‐trained), and in two training periods, 2 or 14 weeks. R and E maximal tests were evaluated before and after the training period. Forty‐eight hours after the end of training program, cerebral cortex, striatum, hippocampus, and cerebellum were extracted for the analysis of autophagy proteins (LC3B‐I, LC3B‐II, and p62). Additionally, hippocampal adult neurogenesis was determined by doublecortin‐positive cells count (DCX+) in brain sections. Our results show that, in contrast to Wt, KO were unable to improve R after both trainings. Autophagy levels in brain areas may be modified by E training only in cerebral cortex of Wt trained for 14 weeks, and in KO trained for 2 weeks. DCX + in Wt increased in R and E after both periods of training, with R for 14 weeks more effective than E. Interestingly, no changes in DCX + were observed in KO after 2 weeks, being even undetectable after 14 weeks of intervention. Thus, autophagy is crucial for R performance and for exercise‐induced adult neurogenesis.

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