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Effects of intense aerobic exercise and/or antihypertensive medication in individuals with metabolic syndrome
Author(s) -
RamirezJimenez M.,
MoralesPalomo F.,
Ortega J. F.,
MoraRodriguez R.
Publication year - 2018
Publication title -
scandinavian journal of medicine and science in sports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.575
H-Index - 115
eISSN - 1600-0838
pISSN - 0905-7188
DOI - 10.1111/sms.13218
Subject(s) - medicine , placebo , blood pressure , aerobic exercise , randomized controlled trial , cardiology , physical therapy , pathology , alternative medicine
We studied the blood pressure lowering effects of a bout of exercise and/or antihypertensive medicine with the goal of studying if exercise could substitute or enhance pharmacologic hypertension treatment. Twenty‐three hypertensive metabolic syndrome patients chronically medicated with angiotensin II receptor 1 blockade antihypertensive medicine underwent 24‐hr monitoring in four separated days in a randomized order; (a) after taking their habitual dose of antihypertensive medicine ( AHM trial), (b) substituting their medicine by placebo medicine ( PLAC trial), (c) placebo medicine with a morning bout of intense aerobic exercise ( PLAC + EXER trial) and (d) combining the exercise and antihypertensive medicine ( AHM + EXER trial). We found that in trials with AHM subjects had lower plasma aldosterone/renin activity ratio evidencing treatment compliance. Before exercise, the trials with AHM displayed lower systolic (130 ± 16 vs 133 ± 15 mm Hg; P = .018) and mean blood pressures (94 ± 11 vs 96 ± 10 mm Hg; P = .036) than trials with placebo medication. Acutely (ie, 30 min after treatments) combining AHM + EXER lowered systolic blood pressure ( SBP ) below the effects of PLAC + EXER (−8.1 ± 1.6 vs −4.9 ± 1.5 mm Hg ; P = .015). Twenty‐four hour monitoring revealed no differences among trials in body motion. However, PLAC + EXER and AHM lowered SBP below PLAC during the first 10 hours, time at which PLAC + EXER effects faded out (ie, at 19 PM ). Adding exercise to medication (ie, AHM + EXER ) resulted in longer reductions in SBP than with exercise alone ( PLAC + EXER ). In summary, one bout of intense aerobic exercise in the morning cannot substitute the long‐lasting effects of antihypertensive medicine in lowering blood pressure, but their combination is superior to exercise alone.