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Altered stress hormone response following acute exercise during prostate cancer treatment
Author(s) -
Hanson E. D.,
Sakkal S.,
Evans W. S.,
Violet J. A.,
Battaglini C. L.,
McConell G. K.,
Hayes A.
Publication year - 2018
Publication title -
scandinavian journal of medicine and science in sports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.575
H-Index - 115
eISSN - 1600-0838
pISSN - 0905-7188
DOI - 10.1111/sms.13199
Subject(s) - medicine , prostate cancer , hormone , endocrinology , epinephrine , hydrocortisone , cancer , androgen deprivation therapy
Exercise training reduces the side effects of cancer treatments; however, the stress hormone response to acute exercise during prostate cancer ( PC a) treatment is unclear. The study purpose was to examine the effects of acute exercise on circulating cortisol, epinephrine (Epi), and norepinephrine ( NE ) concentrations during PC a treatment with and without androgen deprivation therapy ( ADT ). Men with PC a (n = 11), with PC a on ADT (n = 11), and with non‐cancer controls (n = 8) had blood samples for stress hormones collected before and immediately (0 hour), 2 hours, and 24 hours after 45 minutes of intermittent cycling at 60% of peak wattage. NE increased by 385% ( P < .001) at 0 hour and remained elevated at 2 hours ( P < .05) with no group differences. Overall, cortisol significantly increased at 0 hour (36%, P < .012) and then significantly decreased below baseline at 2 hours (−24%, P < .001) before returning to resting levels at 24 hours. Cortisol levels during ADT were 32% lower than PC a ( P = .006) with no differences vs controls. Epi increased immediately after exercise more in controls (817%, P < .001) than with ADT (700%) and PC a (333%) patients, and both cancer groups’ absolute levels were attenuated relative to controls ( ADT : −54%, PC a: −52%, P = .004). Compared with age‐matched controls, PC a and ADT patients exhibited similar stress hormone responses with acute exercise for NE and cortisol but an attenuated EPI response that suggests altered adrenal function. Future studies should examine the physical stress of multiple exercise bouts to verify these findings and to explore the functional hormonal effects, such as immune and metabolic responses, during cancer treatment.