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Cardiopulmonary fitness is strongly associated with body cell mass and fat‐free mass
Author(s) -
Köhler A.,
King R.,
Bahls M.,
Groß S.,
Steveling A.,
Gärtner S.,
Schipf S.,
Gläser S.,
Völzke H.,
Felix S. B.,
Markus M. R. P.,
Dörr M.
Publication year - 2018
Publication title -
scandinavian journal of medicine and science in sports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.575
H-Index - 115
eISSN - 1600-0838
pISSN - 0905-7188
DOI - 10.1111/sms.13057
Subject(s) - bioelectrical impedance analysis , linear regression , normalization (sociology) , medicine , correlation coefficient , fat free mass , confidence interval , population , fat mass , cardiology , body mass index , statistics , mathematics , environmental health , sociology , anthropology
Peak oxygen uptake ( VO 2peak) is commonly indexed by total body weight ( TBW ) to determine cardiopulmonary fitness ( CPF ). This approach may lead to misinterpretation, particularly in obese subjects. We investigated the normalization of VO 2peak by different body composition markers. We analyzed combined data of 3848 subjects (1914 women; 49.7%), aged 20‐90, from two independent cohorts of the population‐based Study of Health in Pomerania ( SHIP ‐2 and SHIP ‐ TREND ). VO 2peak was assessed by cardiopulmonary exercise testing. Body cell mass ( BCM ), fat‐free mass ( FFM ), and fat mass ( FM ) were determined by bioelectrical impedance analysis. The suitability of the different markers as a normalization variable was evaluated by taking into account correlation coefficients ( r ) and intercept (α‐coefficient) values from linear regression models. A combination of high r and low α values was considered as preferable for normalization purposes. BCM was the best normalization variable for VO 2peak ( r = .72; P ≤ .001; α‐coefficient = 63.3 mL/min; 95% confidence interval [ CI ]: 3.48‐123) followed by FFM ( r = .63; P ≤ .001; α‐coefficient = 19.6 mL/min; 95% CI : −57.9‐97.0). On the other hand, a much weaker correlation and a markedly higher intercept were found for TBW ( r = .42; P ≤ .001; α‐coefficient = 579 mL/min; 95% CI : 483 to 675). Likewise, FM was also identified as a poor normalization variable ( r = .10; P ≤ .001; α‐coefficient = 2133; 95% CI : 2074‐2191). Sex‐stratified analyses confirmed the above order for the different normalization variables. Our results suggest that BCM , followed by FFM , might be the most appropriate marker for the normalization of VO 2peak when comparing CPF between subjects with different body shape.