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Serum IL ‐15 and IL ‐15Rα levels are decreased in lean and obese physically active humans
Author(s) -
PérezLópez A.,
Valadés D.,
Vázquez Martínez C.,
Cos Blanco A. I.,
Bujan J.,
GarcíaHonduvilla N.
Publication year - 2018
Publication title -
scandinavian journal of medicine and science in sports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.575
H-Index - 115
eISSN - 1600-0838
pISSN - 0905-7188
DOI - 10.1111/sms.12983
Subject(s) - endocrinology , medicine , chemistry
Circulating IL ‐15 presence is required to stimulate anti‐adipogenic effects of the IL ‐15/ IL ‐15Rα axis in adipose tissue. Although exercise increases blood IL ‐15 expression post‐exercise, it remains inconclusive whether physical activity can alter the baseline concentrations of this cytokine. The aim of this study was to determine whether physical activity regulates circulating IL ‐15 and IL ‐15Rα in lean and obese individuals. Two hundred and seventy‐six participants were divided into five groups according to physical activity ( PA ), body mass and type 2 diabetes mellitus (T2 DM ) diagnosis: (a) lean PA (N = 25); (b) lean non‐ PA (N = 28); (c) obese PA (N = 64); (d) obese non‐ PA (N = 79); and (e) obese non‐ PA with T2 DM (N = 80). Serum IL ‐15 and IL ‐15Rα, blood glucose/lipid profile and body composition were measured. Serum IL ‐15 and IL ‐15Rα decreased in PA participants compared to non‐ PA ( P < .05), while IL ‐15 and IL ‐15Rα increased in obese with T2 DM compared to obese without T2 DM ( P < .05). No differences were observed between lean non‐ PA and obese PA . Serum IL ‐15Rα was associated with fasting glucose ( R 2 = .063), insulin ( R 2 = .082), HbA 1c ( R 2 = .108), and HOMA ( R 2 = .057) in obese participants. Circulating IL ‐15 and IL ‐15Rα are reduced in lean and obese participants who perform physical activity regularly (≥180 min/week), suggesting a regulative role of physical activity on the circulating concentrations of IL ‐15 and IL ‐15Rα at baseline. Moreover, the relationship observed between IL ‐15Rα and glucose profile may indicate a role of the alpha receptor in glucose metabolism.