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Influence of treadmill training on bone structure under osteometabolic alteration in rats subjected to high‐fat diet
Author(s) -
Macedo A. P.,
Shimano R. C.,
Ferrari D. T.,
Issa J. P. M.,
Jordão A. A.,
Shimano A. C.
Publication year - 2017
Publication title -
scandinavian journal of medicine and science in sports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.575
H-Index - 115
eISSN - 1600-0838
pISSN - 0905-7188
DOI - 10.1111/sms.12650
Subject(s) - ovariectomized rat , medicine , endocrinology , bone mineral , fat mass , obesity , bone density , treadmill , osteoporosis , zoology , biology , estrogen
Nutrition and physical training have important roles in the accumulation and maintenance of bone mass. The aim of this study was to evaluate, in ovariectomized rats ( OVX ), the effects of treadmill training (T) with high‐fat diet (F) on weight gain and bone tissue properties with eight groups ( n = 10) for 12 weeks: OVX SC ( OVX , sedentary lifestyle, diet control); OVX SF ; OVX TC ; OVX TF ; SH SC ( SHAM , sedentary lifestyle, diet control); SH SF ; SH TC ; and SH TF . Weekly weight gain and final body composition were assessed. After euthanasia, tibiae were analyzed. The trained animals had higher body weight ( P = 0.001), bone mineral density ( P < 0.001), and trabecular bone ( P < 0.001). The animals with a high‐fat diet showed higher global fat ( P < 0.001), percentage of global fat ( P < 0.001) and deformation at impact ( P = 0.031) and reduced tibial bone mineral content ( P = 0.036). Physical training improves bone microarchitecture, without presenting an increase in impact resistance, and a high‐fat diet increases body fat and impairs bone mineralization.