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Androgen receptor gene polymorphism influence fat accumulation: A longitudinal study from adolescence to adult age
Author(s) -
PonceGonzález J. G.,
RodríguezGarcia L.,
LosaReyna J.,
GuadalupeGrau A.,
RodriguezGonzalez F. G.,
DíazChico B. N.,
Dorado C.,
SerranoSanchez J. A.,
Calbet J. A. L.
Publication year - 2016
Publication title -
scandinavian journal of medicine and science in sports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.575
H-Index - 115
eISSN - 1600-0838
pISSN - 0905-7188
DOI - 10.1111/sms.12587
Subject(s) - androgen receptor , lean body mass , endocrinology , medicine , trunk , fat mass , androgen , young adult , biology , body fat percentage , obesity , body weight , hormone , ecology , prostate cancer , cancer
To determine the influence of androgen receptor CAG and GGN repeat polymorphisms on fat mass and maximal fat oxidation ( MFO ), CAG and GGN repeat lengths were measured in 128 young boys, from which longitudinal data were obtained in 45 of them [mean ± SD : 12.8 ± 3.6 years old at recruitment, and 27.0 ± 4.8 years old at adult age]. Subjects were grouped as CAG short ( CAG S ) if harboring repeat lengths ≤ 21, the rest as CAG long ( CAG L ); and GGN short ( GGN S ) if GGN repeat lengths ≤ 23, or long if > 23 ( GGN L ). CAG S and GGN S were associated with lower adiposity than CAG L or GGN L ( P < 0.05). There was an association between the logarithm of CAG repeats polymorphism and the changes of body mass ( r = 0.34, P = 0.03). At adult age, CAG S men showed lower accumulation of total body and trunk fat mass, and lower resting metabolic rate ( RMR ) and MFO per kg of total lean mass compared with CAG L ( P < 0.05). GGN S men also showed lower percentage of body fat ( P < 0.05). In summary, androgen receptor CAG and GGN repeat polymorphisms are associated with RMR , MFO , fat mass, and its regional distribution in healthy male adolescents, influencing fat accumulation from adolescence to adult age.