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Ibuprofen intake increases exercise time to exhaustion: A possible role for preventing exercise‐induced fatigue
Author(s) -
Lima F. D.,
Stamm D. N.,
Della Pace I. D.,
Ribeiro L. R.,
Rambo L. M.,
Bresciani G.,
Ferreira J.,
Rossato M. F.,
Silva M. A.,
Pereira M. E.,
Ineu R. P.,
Santos A. R.,
Bobinski F.,
Fighera M. R.,
Royes L. F. F.
Publication year - 2016
Publication title -
scandinavian journal of medicine and science in sports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.575
H-Index - 115
eISSN - 1600-0838
pISSN - 0905-7188
DOI - 10.1111/sms.12549
Subject(s) - ibuprofen , medicine , aché , nonsteroidal , saline , anesthesia , endocrinology , acetylcholinesterase , pharmacology , biochemistry , chemistry , enzyme
Although the intake of nonsteroidal anti‐inflammatory drugs ( NSAIDs ) intake by athletes prevents soreness, little is known concerning their role in exercise performance. This study assessed the effects of ibuprofen intake on an exhaustive protocol test after 6 weeks of swimming training in rats. Animals were divided into sedentary and training groups. After training, animals were subdivided into two subsets: saline or ibuprofen. Afterwards, three repeated swimming bouts were performed by the groups. Ibuprofen (15 mg/kg) was administered once a day. Pain measurements were performed and inflammatory and oxidative stress parameters were assayed in cerebral cortex and gastrocnemius muscle. Training, ibuprofen administration, or both combined ( P < 0.05; 211 ± 18s, 200 ± 31s, and 279 ± 23s) increased exercise time to exhaustion. Training decreased the acetylcholinesterase ( AChE ) activity ( P < 0.05; 149 ± 11) in cerebral cortex. Ibuprofen intake decreased the AChE activity after exhaustive protocol test in trained and sedentary rats ( P < 0.05; 270 ± 60; 171 ± 38; and 273 ± 29). It also prevented neuronal tumor necrosis factor‐α ( TNF ‐α) and interleukin ( IL 1β) increase. Fatigue elicited by this exhaustive protocol may involve disturbances of the central nervous system. Additive anti‐inflammatory effects of exercise and ibuprofen intake support the hypothesis that this combination may constitute a more effective approach. In addition, ergogenic aids may be a useful means to prevent exercise‐induced fatigue.