z-logo
Premium
CFTR genotype‐related body water and electrolyte balance during a marathon
Author(s) -
Del Coso J.,
Lara B.,
Salinero J. J.,
Areces F.,
RuizVicente D.,
GalloSalazar C.,
AbiánVicén J.,
Cacabelos R.
Publication year - 2016
Publication title -
scandinavian journal of medicine and science in sports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.575
H-Index - 115
eISSN - 1600-0838
pISSN - 0905-7188
DOI - 10.1111/sms.12542
Subject(s) - sweat , genotype , sodium , hyponatremia , medicine , electrolyte , endocrinology , chemistry , biochemistry , organic chemistry , electrode , gene
The aim of this investigation was to determine the influence of CFTR genotype on body water and electrolyte balance during a marathon. Fifty‐one experienced runners completed a marathon race. Before and after the race, body mass and a sample of venous blood were obtained. During the race, sweat samples were collected using sweat patches, and fluid and electrolyte intake were obtained using self‐reported questionnaires. Thirty‐eight participants (74.5% of the total) were 7T/7T homozygotes, 11 (21.6%) were 7T/9T heterozygotes, and one participant presented the rare genotype 5T/7T. Another participant with 9T/9T presented the mutation p.L206W. Participants with 7T/7T showed higher sweat sodium concentrations (42.2 ± 21.6 mmol/L) than 7T/9T (29.0 ± 24.7 mmol/L; P  = 0.04). The runner with the 5T/7T genotype (10.2 mmol/L) and the participant with the p.L206W mutation (20.5 mmol/L) exhibited low‐range sweat sodium concentrations. However, post‐race serum sodium concentration was similar in 7T/7T and 7T/9T (142.1 ± 1.3 and 142.4 ± 1.6 mmol/L, respectively; P  = 0.27) and did not show abnormalities in participants with the 5T/7T genotype (140.0 mmol/L) and the p.L206W mutation (143.0 mmol/L). Runners with the CFTR ‐7T/7T genotype exhibited increased sweat sodium concentrations during a marathon. However, this phenotype was not related with increased likelihood of suffering body water and electrolyte imbalances during real competitions.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here