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Myostatin dysfunction is associated with reduction in overload induced hypertrophy of soleus muscle in mice
Author(s) -
Minderis P.,
Kilikevicius A.,
Baltusnikas J.,
Alhindi Y.,
Venckunas T.,
Bunger L.,
Lionikas A.,
Ratkevicius A.
Publication year - 2016
Publication title -
scandinavian journal of medicine and science in sports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.575
H-Index - 115
eISSN - 1600-0838
pISSN - 0905-7188
DOI - 10.1111/sms.12532
Subject(s) - myostatin , medicine , endocrinology , muscle hypertrophy , isometric exercise , soleus muscle , phosphorylation , strain (injury) , skeletal muscle , chemistry , biochemistry
The aim of the study was to investigate if myostatin dysfunction would promote the gain in muscle mass and peak isometric force ( P 0 ) of soleus muscle ( SOL ) in response to functional overloading ( FO ) after ablation of the gastrocnemius muscle. Fifteen male B erlin high ( BEH ) mice homozygous for the compact mutation causing dysfunction of myostatin and 17 mice with the corresponding wild‐type allele ( BEH +/+) were subjected to FO of SOL for 28 days at the age of 14 weeks. Compared with BEH +/+ mice, SOL of BEH was heavier (mean ± SD , 13.5 ± 1.5 vs 21.4 ± 1.8 mg, respectively, P < 0.001). After FO , SOL mass increased relatively more in BEH +/+ than BEH strain (34.9 ± 11.5 vs 17.7 ± 11.9%, respectively, P < 0.01). P 0 fell ( P < 0.01) only in BEH strain, which also showed an increase ( P < 0.01) in optimal muscle length. Specific P 0 became even more depressed in BEH compared with BEH +/+ strain (8.4 ± 1.4 vs 10.8 ± 1.3 N /g, respectively, P < 0.001). Phosphorylation p70 S6 kinase did not differ between the strains. In summary, myostatin dysfunction impairs adaptation of SOL muscle to high functional demands.