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The effects of aerobic endurance exercise on pulse wave velocity and intima media thickness in adults: A systematic review and meta‐analysis
Author(s) -
Huang C.,
Wang J.,
Deng S.,
She Q.,
Wu L.
Publication year - 2016
Publication title -
scandinavian journal of medicine and science in sports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.575
H-Index - 115
eISSN - 1600-0838
pISSN - 0905-7188
DOI - 10.1111/sms.12495
Subject(s) - meta analysis , aerobic exercise , medicine , pulse wave velocity , pulse (music) , physical therapy , physical medicine and rehabilitation , cardiology , physics , optics , blood pressure , detector
The aim of this study was to perform a systematic review and meta‐analysis of randomized controlled trials ( RCTs ) or cohort studies that evaluated the effect of aerobic endurance exercise on pulse wave velocity ( PWV ) and intima media thickness ( IMT ) in adults. IMT and PWV were the most commonly used parameters for the assessment of arterial stiffness. The MEDLINE , C ochrane, ISI , and O vid databases were searched between J anuary 2000 and F ebruary 2015. A total of 1654 participants in 26 RCTs and two cohort studies were included in the meta‐analysis. In studies for which PWV was the outcome, aerobic endurance exercise had a significant effect on reducing PWV [−0.67, 95% CI −0.97, −0.38; I 2 = 89%; heterogeneity, P < 0.0001]. Changes in peripheral arterial PWV were statistically greater than in central arterial PWV . In the RCTs for which IMT was the outcome, changes [−0.04, 95% CI −0.12, 0.04; I 2 = 95%; heterogeneity, P < 0.00001] in IMT did not reach statistical significance. In the two cohort studies, changes [−8.81, 95% CI −9.25, −8.37; I 2 = 22%; heterogeneity, P = 0.26] in IMT were statistically significant. Subgroup analysis indicated a longer duration aerobic exercise and a greater improvement in VO 2max were associated with larger reductions in PWV . Reductions in IMT were observed in two cohort studies, but not in four RCTs .