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Effects of acute, intermittent exercise in hypoxic environments on the release of cardiac troponin
Author(s) -
Li F.,
Hu Y.,
Nie J.,
Fu F.H.
Publication year - 2016
Publication title -
scandinavian journal of medicine and science in sports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.575
H-Index - 115
eISSN - 1600-0838
pISSN - 0905-7188
DOI - 10.1111/sms.12463
Subject(s) - medicine , troponin complex , troponin , cardiology , hypoxia (environmental) , troponin i , troponin t , exercise intensity , exercise physiology , heart rate , physical therapy , oxygen , chemistry , blood pressure , myocardial infarction , organic chemistry
The purpose of this study was to examine the effects of acute, intermittent exercise performed in hypoxic environments on the release of cardiac troponin ( cTn ). Ten well‐trained, male marathon runners (22.1 ± 2.6 years, 64.0 ± 4.9 kg and 177.3 ± 3.9 cm) completed three intermittent exercise protocols under normoxic (trial N ) and hypoxic (trial AH and RH ) conditions. In trial N , the fraction of inspiration oxygen ( FIO 2 ) was 21.0% and exercise intensity was 90% and 50% normoxic velocity of VO 2max ( vVO 2max ). In trial AH , FIO 2 was 14.4% (simulated altitude of 3000 m) and exercise intensity was 90% and 50% normoxic vVO 2max . In trial RH , FIO 2 was 14.4% and exercise intensity was 90% and 50% hypoxic vVO 2max . High‐sensitivity cardiac troponin T ( hs ‐ cTnT ) and cardiac troponin I ( cTnI ) were measured pre‐ and 0, 2, 4, and 24 h post‐exercise. Hs‐ cTnT was elevated in all three trials, peaking at 2 to 4 h and returning to the baseline 24 h post‐exercise. CTnI increased in trial AH , peaking at 2 to 4 h and returning below the detection limit 24 h post‐exercise. It is concluded that the stimulus of hypoxia did not in and of itself induce more cTn to be released, but exercise intensity could affect this response in hypoxic environments.