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Influence of 4 weeks of bovine colostrum supplementation on neutrophil and mucosal immune responses to prolonged cycling
Author(s) -
Jones A. W.,
Thatcher R.,
March D. S.,
Davison G.
Publication year - 2015
Publication title -
scandinavian journal of medicine and science in sports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.575
H-Index - 115
eISSN - 1600-0838
pISSN - 0905-7188
DOI - 10.1111/sms.12433
Subject(s) - respiratory burst , lactoferrin , saliva , medicine , immune system , oxidative stress , immunology , lysozyme , endocrinology , colostrum , granulocyte , neutrophile , antibody , inflammation , chemistry , biochemistry
Bovine colostrum ( COL ) has been advocated as a nutritional countermeasure to exercise‐induced immune dysfunction. The aims of this study were to identify the effects of 4 weeks of COL supplementation on neutrophil responses and mucosal immunity following prolonged exercise. In a randomized double‐blind, parallel group design, participants [age 28 ± 8 years; body mass 79 ± 7 kg; height 182 ± 6 cm; maximal oxygen uptake ( V ˙ O 2 m a x) 55 ± 9 mL/kg/min] were assigned to 20 g per day of COL ( n = 10) or an isoenergetic/isomacronutrient placebo ( PLA ; n = 10) for 4 weeks. Venous blood and unstimulated saliva samples were obtained before and after 2.5 h of cycling at 15% Δ (∼55–60%V ˙ O 2 m a x). A significantly greater formyl‐methionyl‐leucyl phenylalanine‐stimulated oxidative burst was observed in the COL group compared with PLA group ( P < 0.05) and a trend toward a time × group interaction ( P = 0.06). However, there was no effect of COL on leukocyte trafficking, phorbol‐12‐myristate‐13‐acetate‐stimulated oxidative burst, bacterial‐stimulated neutrophil degranulation, salivary secretory IgA , lactoferrin or lysozyme ( P > 0.05). These findings provide further evidence of the beneficial effects of COL on receptor‐mediated stimulation of neutrophil oxidative burst in a model of exercise‐induced immune dysfunction.