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Differences in MCT 1 A 1470 T polymorphism prevalence between runners and swimmers
Author(s) -
BenZaken S.,
Eliakim A.,
Nemet D.,
Rabinovich M.,
Kassem E.,
Meckel Y.
Publication year - 2015
Publication title -
scandinavian journal of medicine and science in sports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.575
H-Index - 115
eISSN - 1600-0838
pISSN - 0905-7188
DOI - 10.1111/sms.12226
Subject(s) - allele frequency , athletes , blood lactate , genotype , genotyping , allele , genotype frequency , anaerobic exercise , medicine , biology , physical therapy , genetics , heart rate , gene , blood pressure
Skeletal muscle is the major producer and user of lactate in the body. Therefore, transport of lactate across cells' membrane is of considerable importance. Lactate transport is mediated by proton‐linked monocarboxylate transporter ( MCT 1). The A 1470 T polymorphism (rs1049434) in MCT1 gene influences lactate transport, with T allele associated with reduction of lactate transport rate and elevation in blood lactate levels. The aim of the current study was to compare allelic and genotype frequencies of MCT 1 A 1470 T polymorphism among I sraeli track‐and‐field athletes, swimmers, and non‐athletes. Genomic DNA was extracted from 173 track‐and‐field athletes (age 17–50), 80 swimmers (age 16–49), and 128 non‐athletes (age 19–29). Track‐and‐field athletes were assigned to three subgroups: long‐distance runners, middle‐distance runners, and power event athletes. Swimmers were assigned to two subgroups: long‐distance swimmers and short‐distance swimmers. Genotyping was performed using polymerase chain reaction. T ‐allele frequency was significantly higher among long‐distance swimmers (45%) compared with long‐ and middle‐distance runners (27% and 30%, respectively; P < 0.01). In addition, T ‐allele frequency was significantly higher among short‐distance swimmers (40%) compared with power event athletes (25%, P < 0.01). Overall, T‐allele frequency was significantly higher among swimmers (42%) compared with runners (27%, P < 0.001). More research is needed to clarify whether this polymorphism displays advantage for swimming performance.