Tryptophan Hydroxylase 1 Variant rs1800532 is Associated with Suicide Attempt in Serbian Psychiatric Patients but does not Moderate the Effect of Recent Stressful Life Events | Zendy

Karanović Jelena | Zendy; Ivković Maja | Zendy; Jovanović Vladimir M. | Zendy; Pantović Maja | Zendy; PavlovićJanković Nataša | Zendy; Damjanović Aleksandar | Zendy; Brajušković Goran | Zendy; Romac Stanka | Zendy; SavićPavićević Dušanka | Zendy

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Tryptophan Hydroxylase 1 Variant rs1800532 is Associated with Suicide Attempt in Serbian Psychiatric Patients but does not Moderate the Effect of Recent Stressful Life Events

Author(s) -

Karanović Jelena,

Ivković Maja,

Jovanović Vladimir M.,

Pantović Maja,

PavlovićJanković Nataša,

Damjanović Aleksandar,

Brajušković Goran,

Romac Stanka,

SavićPavićević Dušanka

Publication year - 2016

Publication title -

suicide and life‐threatening behavior

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.544

H-Index - 90

eISSN - 1943-278X

pISSN - 0363-0234

DOI - 10.1111/sltb.12246

Subject(s) - tryptophan hydroxylase , psychiatry , serbian , medicine , clinical psychology , psychology , serotonin , serotonergic , linguistics , philosophy , receptor

Tryptophan hydroxylase 1 ( TPH 1) gene, coding for serotonin synthesizing enzyme, and recent stressful life events ( SLE s) have been commonly associated with suicidal behavior. TPH 1 has been also hypothesized to be involved in stress–response mechanisms. The aim of this study was to assess TPH 1 variant rs1800532 and its possible interaction with recent SLE s as risk factors for suicide attempt ( SA ) in Serbian psychiatric patients, including 165 suicide attempters and 188 suicide nonattempters. rs1800532 and recent SLE s were independently associated with SA , while rs1800532 did not moderate the effect of recent SLE s on SA vulnerability among Serbian psychiatric patients.

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