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Tryptophan Hydroxylase 1 Variant rs1800532 is Associated with Suicide Attempt in Serbian Psychiatric Patients but does not Moderate the Effect of Recent Stressful Life Events
Author(s) -
Karanović Jelena,
Ivković Maja,
Jovanović Vladimir M.,
Pantović Maja,
PavlovićJanković Nataša,
Damjanović Aleksandar,
Brajušković Goran,
Romac Stanka,
SavićPavićević Dušanka
Publication year - 2016
Publication title -
suicide and life‐threatening behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.544
H-Index - 90
eISSN - 1943-278X
pISSN - 0363-0234
DOI - 10.1111/sltb.12246
Subject(s) - tryptophan hydroxylase , psychiatry , serbian , medicine , clinical psychology , psychology , serotonin , serotonergic , linguistics , philosophy , receptor
Tryptophan hydroxylase 1 ( TPH 1) gene, coding for serotonin synthesizing enzyme, and recent stressful life events ( SLE s) have been commonly associated with suicidal behavior. TPH 1 has been also hypothesized to be involved in stress–response mechanisms. The aim of this study was to assess TPH 1 variant rs1800532 and its possible interaction with recent SLE s as risk factors for suicide attempt ( SA ) in Serbian psychiatric patients, including 165 suicide attempters and 188 suicide nonattempters. rs1800532 and recent SLE s were independently associated with SA , while rs1800532 did not moderate the effect of recent SLE s on SA vulnerability among Serbian psychiatric patients.