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Optimal and Robust Designs for Estimating the Concentration Curve and the AUC
Author(s) -
Belouni Mohamad,
Benhenni Karim
Publication year - 2015
Publication title -
scandinavian journal of statistics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.359
H-Index - 65
eISSN - 1467-9469
pISSN - 0303-6898
DOI - 10.1111/sjos.12116
Subject(s) - mathematics , estimator , minimax , minimum variance unbiased estimator , autocorrelation , statistics , linear model , minimax estimator , optimal design , asymptotic distribution , asymptotically optimal algorithm , mathematical optimization
The problem of interest is to estimate the concentration curve and the area under the curve (AUC) by estimating the parameters of a linear regression model with an autocorrelated error process. We introduce a simple linear unbiased estimator of the concentration curve and the AUC. We show that this estimator constructed from a sampling design generated by an appropriate density is asymptotically optimal in the sense that it has exactly the same asymptotic performance as the best linear unbiased estimator. Moreover, we prove that the optimal design is robust with respect to a minimax criterion. When repeated observations are available, this estimator is consistent and has an asymptotic normal distribution. Finally, a simulated annealing algorithm is applied to a pharmacokinetic model with correlated errors.