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Dual roles of granzyme B
Author(s) -
Wang Huiling,
Huang Yong,
He Jian,
Zhong Liping,
Zhao Yongxiang
Publication year - 2021
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/sji.13086
Subject(s) - granzyme b , granzyme , immunology , biology , immune system , perforin , cd8
Granzyme B (GZMB) was first identified as a factor that could eliminate cells such as tumour cells and bacteria/virus‐infected cells. However, comprehensive studies conducted on GZMB have gradually revealed the negative extracellular functions of GZMB; for example, it is an aetiology and a factor responsible for the aggravation of several diseases. This review focuses on the positive role of GZMB (in the elimination of tumour cells, bacteria, parasites and viruses, and in the identification, diagnosis and treatment of diseases) and the negative effects of GZMB (with regard to extracellular function and other characteristics). The current research on GZMB inhibitors has been briefly introduced, and few studies on GZMB fusion proteins and several GZMB material delivery systems have been discussed.