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Serum‐soluble PD‐L1 may be a potential diagnostic biomarker in sepsis
Author(s) -
Sun Shaoqiong,
Chen Yang,
Liu Zhaojun,
Tian Rui,
Liu Jialin,
Chen Erzhen,
Mao Enqiang,
Pan Tingting,
Qu Hongping
Publication year - 2021
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/sji.13049
Subject(s) - sepsis , biomarker , medicine , acute pancreatitis , gastroenterology , sofa score , area under the curve , pancreatitis , biochemistry , chemistry
To investigate whether serum‐soluble PD‐L1 (sPD‐L1) is a potential biomarker for identifying sepsis. This study enrolled 64 septic patients, 29 patients with acute appendicitis, 33 patients with acute pancreatitis and 30 healthy volunteers. Sepsis was defined according to the Sepsis 3.0 criteria.[1] The associated clinical parameters were recorded, blood samples were collected on the first day of diagnosis, and serum sPD‐L1 levels were measured using enzyme‐linked immunosorbent assays. Compared with the control group, a significant increase in sPD‐L1 levels was observed in patients with sepsis (n = 64). Increased sPD‐L1 expression correlated strongly with increased clinical inflammatory values (CRP, PCT and WBC) and decreased immunological functional parameters (CD3 + , CD4 + and CD8 + cell counts). The area under the ROC curve (AUC) for sPD‐L1 in combination with the sequential organ failure assessment (SOFA) score was superior to the AUC for either sPD‐L1 or SOFA score in regard to the diagnosis of sepsis. sPD‐L1 may represent a valuable biomarker for the diagnosis of sepsis.