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The attentive focus on T cell‐mediated autoimmune pathogenesis of psoriasis, lichen planus and vitiligo
Author(s) -
Aghamajidi Azin,
Raoufi Ehsan,
Parsamanesh Gilda,
Jalili Ahmad,
SalehiShadkami Mohammad,
Mehrali Marjan,
Mohsenzadegan Monireh
Publication year - 2021
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/sji.13000
Subject(s) - vitiligo , psoriasis , immunology , medicine , immune system , pathogenesis , pathophysiology , autoimmunity , dermatology , pathology
Abstract T cell‐mediated autoimmune skin diseases develop as a result of the aberrant immune response to the skin cells with T cells playing a central role. These chronic inflammatory skin diseases encompass various types including psoriasis, lichen planus and vitiligo. These diseases show similarities in their immune‐pathophysiology. In the last decade, immunomodulating agents have been very successful in the management of these diseases thanks to a better understanding of the pathophysiology. In this review, we will discuss the immunopathogenic mechanisms and highlight the role of T lymphocytes in psoriasis, lichen planus and vitiligo. This study could provide new insights into a better understanding of targeted therapeutic pathways and biological therapies.